Multiple primary malignancies: synchronous urothelial carcinoma of the bladder and adenocarcinoma of the colon

The symptoms of SMD vary depending on the age of the patients (1) , the principal symptoms being as follows: limited postna-tal growth; rhizomelic shortening of the limbs in early childhood evolving to shortening of the trunk by the age of 10 years; tho-racic hypoplasia, which causes respiratory problems in the neona-tal period and increases susceptibility to respiratory tract infection (4) ; scoliosis with dorsal kyphosis; abnormalities of the meta-physes and pelvis (5) ; odontoid hypoplasia; and valgus of the knees and claudication (6) , the latter typically being the first sign of the disease (2). There might be little or no ossification of the cervical vertebrae, leading to cervical instability and swan neck deformity (7). A review of the literature revealed that there are currently 10 recognized subtypes of SMD. However, there in no consensus in the medical literature regarding those subtypes, because they are based characteristics that are minimally different. Some subtypes are based on reports of only one case, and others can be diagnosed only after years of follow-up, which is difficult. For example, the longest follow-up period in a report of Sedaghatian-type SMD was 161 days. Therefore, there is no acceptable standard for subclas-sifying the disease. dysplasia: a case report with literature review. Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia. et al. Severe neurologic manifestations from cervical spine instability in spondylo-megaepiphyseal-metaphyseal dysplasia. A 75-year-old White male presented with a three-month history of pain in the left hypochondrium. The patient also reported experiencing an episode of gross hematuria six months prior. He had quit smoking 20 years prior, having previously smoked 30 ciga-rettes/day for 30 years. He had also undergone surgery for a gastric ulcer 20 years prior. He reported no other comorbidities. Computed tomography of the abdomen showed a solid, irregular , concentric mass, which was expansive and stenotic, in the middle third of the descending colon (Figures 1A and 1B). The mass showed heterogeneous uptake of the intravenous iodi-nated contrast medium and increased density of adjacent fat tissue , suggesting that it had expanded through the serosa. In addition , a vegetative lesion, with irregular borders and showing contrast enhancement, was observed in the right posterolateral wall of the bladder (Figures 1B and 1C). Colonoscopy with biopsy of the intestinal mass led to a histo-logical diagnosis of moderately differentiated adenocarcinoma of the colon, and …